ESR8

Post no.

ESR 8

Duration

36 months

Work package

WP3, D3.1: Design, synthesis and pre-clinical evaluation of multifunctional 161Tb complexes for cell specific targeting of DNA

Recruiting partner

Instituto Superior Técnico Lisbon, Portugal

Objective

161Terbium Auger-emitting radiopharmaceuticals for the eradication of large tumor masses or small metastases for ovarian cancers

Expected results

  1. Synthesis and characterization of macrocyclic bifunctional chelators (e.g. 1,4,7,10-tetraazacyclododecane DOTA) bearing a tumor-specific MAb fragment targeting moiety and a DNA-binding moiety).
  2. Synthesis of cold Tb complexes and characterization by spectroscopic techniques.
  3. Biological evaluation of Tb-161 complexes (Damage in plasmid DNA, Cell uptake using human tumor cell lines, Radiotoxicity and mechanisms of cell death, Biodistribution and SPECT imaging in tumor-bearing mice)

Enrolment for PhD at

Instituto Superior Técnico Lisbon, Portugal

Planned secondment(s)

CHUV, Switzerland – 2 months – μPET-SPECT imaging in nude mice

EPFL, Switzerland – 8 months – Synthesis of bifunctional fluorescent-Auger emitting bioligand targetting ovarian cancer DNA

 
 

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